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Target
Somatostatin receptor type 3
Ligand
BDBM50400524
Substrate
n/a
Meas. Tech.
ChEMBL_879796 (CHEMBL2210524)
IC50
0.460000±n/a nM
Citation
 He, S; Ye, Z; Truong, Q; Shah, S; Du, W; Guo, L; Dobbelaar, PH; Lai, Z; Liu, J; Jian, T; Qi, H; Bakshi, RK; Hong, Q; Dellureficio, J; Pasternak, A; Feng, Z; deJesus, R; Yang, L; Reibarkh, M; Bradley, SA; Holmes, MA; Ball, RG; Ruck, RT; Huffman, MA; Wong, F; Samuel, K; Reddy, VB; Mitelman, S; Tong, SX; Chicchi, GG; Tsao, KL; Trusca, D; Wu, M; Shao, Q; Trujillo, ME; Eiermann, GJ; Li, C; Zhang, BB; Howard, AD; Zhou, YP; Nargund, RP; Hagmann, WK The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes. ACS Med Chem Lett 3:484-489 (2012) [PubMed]  Article 
Target
Name:
Somatostatin receptor type 3
Synonyms:
SOMATOSTATIN SST3 | SS3R | SSR-28 | SSR3_MOUSE | Smstr3 | Somatostatin receptor | Somatostatin receptor 3 | Somatostatin receptor type 3 | Sstr3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47225.49
Organism:
MOUSE
Description:
SOMATOSTATIN SST3 SSTR3 MOUSE::P30935
Residue:
428
Sequence:
MATVTYPSSEPTTLDPGNASSTWPLDTTLGNTSAGASLTGLAVSGILISLVYLVVCVVGLLGNSLVIYVVLRHTSSPSVTSVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRTAFIIYTAALGFFGPLLVICLCYLLIVVKVRSTTRRVRAPSCQWVQAPACQRRRRSERRVTRMVVAVVALFVLCWMPFYLLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRILLRPSRRIRSQEPGSGPPEKTEEEEDEEEEERREEEERRMQRGQEMNGRLSQIAQAGTSGQQPRPCTGTAKEQQLLPQEATAGDKASTLSHL
  
Inhibitor
Name:
BDBM50400524
Synonyms:
CHEMBL2204939
Type:
Small organic molecule
Emp. Form.:
C28H25FN8
Mol. Mass.:
492.5501
SMILES:
Cn1cc(cn1)C1(N[C@H](Cc2c1[nH]c1ccccc21)c1nc(c[nH]1)-c1ccc(F)cc1)c1cnn(C)c1 |r|
Structure:
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