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TargetAminopeptidase N
LigandBDBM50400541
Substrate/Competitorn/a
Meas. Tech.ChEMBL_879875
IC50 5610±n/a nM
Citation Su, LCao, JJia, YZhang, XFang, HXu, W Development of Synthetic Aminopeptidase N/CD13 Inhibitors to Overcome Cancer Metastasis and Angiogenesis. ACS Med Chem Lett3:959-964 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aminopeptidase N
Name:Aminopeptidase N
Synonyms:AP-M | AP-N | Alanyl aminopeptidase | Anpep | CD_antigen=CD13 | Lap-1 | Lap1 | Membrane protein p161 | Microsomal aminopeptidase | mAPN
Type:PROTEIN
Mol. Mass.:109642.29
Organism:Mus musculus
Description:ChEMBL_879875
Residue:966
Sequence:
MAKGFYISKTLGILGILLGVAAVCTIIALSVVYAQEKNRNAENSATAPTLPGSTSATTAT
TTPAVDESKPWNQYRLPKTLIPDSYRVILRPYLTPNNQGLYIFQGNSTVRFTCNQTTDVI
IIHSKKLNYTLKGNHRVVLRTLDGTPAPNIDKTELVERTEYLVVHLQGSLVEGRQYEMDS
QFQGELADDLAGFYRSEYMEGDVKKVVATTQMQAADARKSFPCFDEPAMKAMFNITLIYP
NNLIALSNMLPKESKPYPEDPSCTMTEFHSTPKMSTYLLAYIVSEFKNISSVSANGVQIG
IWARPSAIDEGQGDYALNVTGPILNFFAQHYNTSYPLPKSDQIALPDFNAGAMENWGLVT
YRESSLVFDSQSSSISNKERVVTVIAHELAHQWFGNLVTVAWWNDLWLNEGFASYVEYLG
ADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSSPADEIKTPDQIMELFDSITYSKGA
SVIRMLSSFLTEDLFKKGLSSYLHTYQYSNTVYLDLWEHLQKAVNQQTAVQPPATVRTIM
DRWILQMGFPVITVNTNTGEISQKHFLLDSKSNVTRPSEFNYIWIAPIPFLKSGQEDHYW
LDVEKNQSAKFQTSSNEWILLNINVTGYYLVNYDENNWKKLQNQLQTDLSVIPVINRAQI
IHDSFNLASAKMIPITLALDNTLFLVKEAEYMPWQAALSSLNYFTLMFDRSEVYGPMKRY
LKKQVTPLFFYFQNRTNNWVNRPPTLMEQYNEINAISTACSSGLKECRDLVVELYSQWMK
NPNNNTIHPNLRSTVYCNAIAFGGEEEWNFAWEQFRNATLVNEADKLRSALACSKDVWIL
NRYLSYTLNPDYIRKQDTTSTIISIASNVAGHPLVWDFVRSNWKKLFENYGGGSFSFANL
IQGVTRRFSSEFELQQLEQFKADNSATGFGTGTRALEQALEKTRANIDWVKENKDAVFKW
FTENSS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50400541
NameBDBM50400541
Synonyms:CHEMBL2204950
TypeSmall organic molecule
Emp. Form.C15H23N3O4
Mol. Mass.309.3608
SMILESCOc1cccc(CNC(=O)N[C@@H](CC(C)C)C(=O)NO)c1 |r|
Structure
n/a