Target
Potassium voltage-gated channel subfamily KQT member 2
Ligand
BDBM50410081
Substrate
n/a
Meas. Tech.
ChEMBL_310664 (CHEMBL838011)
EC50
10±n/a nM
Citation
 L'Heureux, AMartel, AHe, HChen, JSun, LQStarrett, JENatale, JDworetzky, SIKnox, RJHarden, DGWeaver, DThompson, MWWu, YJ (S,E)-N-[1-(3-heteroarylphenyl)ethyl]-3-(2-fluorophenyl)acrylamides: synthesis and KCNQ2 potassium channel opener activity. Bioorg Med Chem Lett 15:363-6 (2004) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily KQT member 2
Synonyms:
KCNQ2_MOUSE | KQT-like 2 | Kcnq2 | Kqt2 | Potassium channel subunit alpha KvLQT2 | Potassium voltage-gated channel subfamily KQT member 2 | Voltage-gated potassium channel subunit Kv7.2
Type:
PROTEIN
Mol. Mass.:
84494.02
Organism:
Mus musculus
Description:
ChEMBL_990142
Residue:
759
Sequence:
MVQKSRNGGVYPGTSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRPKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMYRLIPPLNQLELLRNLKSKSGLTFRKEPQPEPSPSQKVSLKDRVFSSPRGMAAKGKGSPQAQTVRRSPSADQSLDDSPSKVPKSWSFGDRSRTRQAFRIKGAASRQNSEEASLPGEDIVEDNKSCNCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRIDMIVGPPPPSTPRDKKYPTKGPTAPSRESPQYSPRVDHIVGRGPTITDKDRTKGPAETELPEDPSMMGRLGKVEKQVLSMEKKLDFLVSIYTQRMGIPPAETEAYFGAKEPEPAPPYHSPEDSRDHADKHGCIIKIVRSTSSTGQRNYAAPPAIPPAQCPPSTSWQQSHQRHGTSPVGDHGSLVLRLERSAGMMSCH
  
Inhibitor
Name:
BDBM50410081
Synonyms:
CHEMBL361184
Type:
Small organic molecule
Emp. Form.:
C22H18F2N2O
Mol. Mass.:
364.3879
SMILES:
C[C@H](NC(=O)\C=C\c1ccccc1F)c1cccc(c1)-c1ccc(F)nc1
Structure:
Search PDB for entries with ligand similarity: