Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1D
Ligand
BDBM50410426
Substrate
n/a
Meas. Tech.
ChEMBL_321089 (CHEMBL883692)
Ki
0.501±n/a nM
Citation
 Heightman, TD; Gaster, LM; Pardoe, SL; Pilleux, JP; Hadley, MS; Middlemiss, DN; Price, GW; Roberts, C; Scott, CM; Watson, JM; Gordon, LJ; Holland, VA; Powles, J; Riley, GJ; Stean, TO; Trail, BK; Upton, N; Austin, NE; Ayrton, AD; Coleman, T; Cutler, L 8-Piperazinyl-2,3-dihydropyrrolo[3,2-g]isoquinolines: potent, selective, orally bioavailable 5-HT1 receptor ligands. Bioorg Med Chem Lett 15:4370-4 (2005) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1D
Synonyms:
5-HT-1D | 5-HT-1D-alpha | 5-HT1D | 5-hydroxytryptamine receptor 1D (5-HT1D) | 5HT1D_HUMAN | HTR1D | HTR1DA | HTRL | Serotonin (5-HT) receptor | Serotonin Receptor 1D
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41920.63
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells.
Residue:
377
Sequence:
MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS
  
Inhibitor
Name:
BDBM50410426
Synonyms:
CHEMBL370852
Type:
Small organic molecule
Emp. Form.:
C23H23ClN4O
Mol. Mass.:
406.908
SMILES:
CN1CCN(CC1)c1nccc2cc3CCN(C(=O)c4ccc(Cl)cc4)c3cc12
Structure:
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