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Target
Histidine-rich protein PFHRP-II
Ligand
BDBM22985
Substrate
n/a
Meas. Tech.
ChEMBL_425633 (CHEMBL912571)
IC50
1690000000±n/a nM
Citation
 Gemma, S; Campiani, G; Butini, S; Kukreja, G; Joshi, BP; Persico, M; Catalanotti, B; Novellino, E; Fattorusso, E; Nacci, V; Savini, L; Taramelli, D; Basilico, N; Morace, G; Yardley, V; Fattorusso, C Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore. J Med Chem 50:595-8 (2007) [PubMed]  Article 
Target
Name:
Histidine-rich protein PFHRP-II
Synonyms:
HRP1_PLAFA | Histidine-rich protein | Histidine-rich protein PFHRP-II
Type:
PROTEIN
Mol. Mass.:
35156.49
Organism:
Plasmodium falciparum
Description:
ChEMBL_500704
Residue:
332
Sequence:
MVSFSKNKVLSAAVFASVLLLDNNNSAFNNNLCSKNAKGLNLNKRLLHETQAHVDDAHHAHHVADAHHAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAAYAHHAHHASDAHHAADAHHAAYAHHAHHAADAHHAADAHHAAYAHHAHHAADAHHAADAHHATDAHHAHHAADAHHATDAHHAADAHHAADAHHATDAHHAADAHHATDAHHAADAHHAADAHHATDSHHAHHAADAHHAAAHHATDAHHAAAHHATDAHHAAAHHEAATHCLRH
  
Inhibitor
Name:
BDBM22985
Synonyms:
Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chlorochin | Chloroquine | Chloroquine, 17 | med.21724, Compound 8 | {4-[(7-chloroquinolin-4-yl)amino]pentyl}diethylamine
Type:
Antimalarial
Emp. Form.:
C18H26ClN3
Mol. Mass.:
319.872
SMILES:
CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12
Structure:
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