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Target
Proteinase-activated receptor 2
Ligand
BDBM50412708
Substrate
n/a
Meas. Tech.
ChEMBL_511265 (CHEMBL996091)
EC50
31.62±n/a nM
Citation
 Seitzberg, JG; Knapp, AE; Lund, BW; Mandrup Bertozzi, S; Currier, EA; Ma, JN; Sherbukhin, V; Burstein, ES; Olsson, R Discovery of potent and selective small-molecule PAR-2 agonists. J Med Chem 51:5490-3 (2008) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 2
Synonyms:
F2RL1 | GPR11 | PAR2 | PAR2_HUMAN
Type:
PROTEIN
Mol. Mass.:
44152.54
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1497756
Residue:
397
Sequence:
MRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY
  
Inhibitor
Name:
BDBM50412708
Synonyms:
AC-264613 | CHEMBL494502
Type:
Small organic molecule
Emp. Form.:
C19H18BrN3O2
Mol. Mass.:
400.269
SMILES:
CC(=NNC(=O)[C@H]1[C@@H](CNC1=O)c1ccccc1)c1cccc(Br)c1 |r,w:2.2|
Structure:
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