Target
C-C chemokine receptor type 8
Ligand
BDBM50414957
Substrate
n/a
Meas. Tech.
ChEMBL_594037 (CHEMBL1045844)
IC50
19.05±n/a nM
Citation
 Shamovsky, Ide Graaf, CAlderin, LBengtsson, MBladh, HBörjesson, LConnolly, SDyke, HJvan den Heuvel, MJohansson, HJosefsson, BGKristoffersson, ALinnanen, TLisius, AMännikkö, RNordén, BPrice, SRipa, LRognan, DRosendahl, ASkrinjar, MUrbahns, K Increasing selectivity of CC chemokine receptor 8 antagonists by engineering nondesolvation related interactions with the intended and off-target binding sites. J Med Chem 52:7706-23 (2009) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 8
Synonyms:
CCR8 | CCR8_HUMAN | CKRL1 | CMKBR8 | CMKBRL2
Type:
PROTEIN
Mol. Mass.:
40855.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_454278
Residue:
355
Sequence:
MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL
  
Inhibitor
Name:
BDBM50414957
Synonyms:
CHEMBL429436
Type:
Small organic molecule
Emp. Form.:
C29H31ClN2O2
Mol. Mass.:
475.022
SMILES:
Clc1ccc(cc1)C(=O)N1CCC2(CCN(Cc3cccc(Oc4ccccc4)c3)CC2)CC1
Structure:
Search PDB for entries with ligand similarity: