Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 1
Ligand
BDBM50240908
Substrate
n/a
Meas. Tech.
ChEMBL_837503 (CHEMBL2075991)
IC50
10000±n/a nM
Citation
 Dresser, MJ; Xiao, G; Leabman, MK; Gray, AT; Giacomini, KM Interactions of n-tetraalkylammonium compounds and biguanides with a human renal organic cation transporter (hOCT2). Pharm Res 19:1244-7 (2002) [PubMed]  Article 
Target
Name:
Solute carrier family 22 member 1
Synonyms:
Adrenergic Alpha | OCT1 | Organic cation transporter 1 | S22A1_HUMAN | SLC22A1 | Solute carrier family 22 member 1 | hOCT1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
61154.85
Organism:
Homo sapiens (Human)
Description:
Adrenergic Alpha 0 HUMAN::O15245
Residue:
554
Sequence:
MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLGRKAKPKENTIYLKVQTSEPSGT
  
Inhibitor
Name:
BDBM50240908
Synonyms:
CHEMBL170988 | N''-[(E)-amino(imino)methyl]-N-(2-phenylethyl)guanidine | N''-{amino[(2-phenylethyl)imino]methyl}guanidine | N-(2-phenylethyl)imidodicarbonimidic diamide | N-(2-phenylethyl)imidodicarbonimidic diamide(Phenformin) | N-amino(imino)methyl-N-phenethyliminomethanediamine(Phenformin) | PHENFORMIN
Type:
Small organic molecule
Emp. Form.:
C10H15N5
Mol. Mass.:
205.2596
SMILES:
NC(=N)N=C(N)NCCc1ccccc1 |w:3.2|
Structure:
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