Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM43821
Substrate
n/a
Meas. Tech.
ChEMBL_937333 (CHEMBL2319367)
EC50
>30000±n/a nM
Citation
Sheffler, DJ; Sevel, C; Le, U; Lovell, KM; Tarr, JC; Carrington, SJ; Cho, HP; Digby, GJ; Niswender, CM; Conn, PJ; Hopkins, CR; Wood, MR; Lindsley, CW Further exploration of M1 allosteric agonists: subtle structural changes abolish M1 allosteric agonism and result in pan-mAChR orthosteric antagonism. Bioorg Med Chem Lett 23:223-7 (2012) [PubMed] Article
More Info.:
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_RAT | Cholinergic, muscarinic M2 | Chrm-2 | Chrm2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51555.53
Organism:
RAT
Description:
P10980
Residue:
466
Sequence:
MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
Inhibitor
Name:
BDBM43821
Synonyms:
4-(2-benzamidoethylamino)-1-piperidinecarboxylic acid ethyl ester;hydrochloride | 4-(2-benzamidoethylamino)piperidine-1-carboxylic acid ethyl ester;hydrochloride | CHEMBL1609153 | VU0184670 | cid_25010774 | ethyl 4-(2-benzamidoethylamino)piperidine-1-carboxylate;hydrochloride
Type:
Small organic molecule
Emp. Form.:
C17H25N3O3
Mol. Mass.:
319.3987
SMILES:
CCOC(=O)N1CCC(CC1)NCCNC(=O)c1ccccc1