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Target
Histo-blood group ABO system transferase
Ligand
BDBM50427444
Substrate
n/a
Meas. Tech.
ChEMBL_941222 (CHEMBL2329772)
IC50
389000±n/a nM
Citation
 Schaefer, K; Sindhuwinata, N; Hackl, T; Kötzler, MP; Niemeyer, FC; Palcic, MM; Peters, T; Meyer, B A nonionic inhibitor with high specificity for the UDP-Gal donor binding site of human blood group B galactosyltransferase: design, synthesis, and characterization. J Med Chem 56:2150-4 (2013) [PubMed]  Article 
Target
Name:
Histo-blood group ABO system transferase
Synonyms:
A transferase | ABO | B transferase | BGAT_HUMAN | Fucosylglycoprotein 3-alpha-galactosyltransferase | Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase | Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form | Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase | Glycoprotein-fucosylgalactoside alpha-galactosyltransferase | Histo-blood group A transferase | Histo-blood group B transferase | NAGAT
Type:
PROTEIN
Mol. Mass.:
40947.46
Organism:
Homo sapiens (Human)
Description:
ChEMBL_941222
Residue:
354
Sequence:
MAEVLRTLAGKPKCHALRPMILFLIMLVLVLFGYGVLSPRSLMPGSLERGFCMAVREPDHLQRVSLPRMVYPQPKVLTPCRKDVLVVTPWLAPIVWEGTFNIDILNEQFRLQNTTIGLTVFAIKKYVAFLKLFLETAEKHFMVGHRVHYYVFTDQPAAVPRVTLGTGRQLSVLEVRAYKRWQDVSMRRMEMISDFCERRFLSEVDYLVCVDVDMEFRDHVGVEILTPLFGTLHPGFYGSSREAFTYERRPQSQAYIPKDEGDFYYLGGFFGGSVQEVQRLTRACHQAMMVDQANGIEAVWHDESHLNKYLLRHKPTKVLSPEYLWDQQLLGWPAVLRKLRFTAVPKNHQAVRNP
  
Inhibitor
Name:
BDBM50427444
Synonyms:
CHEMBL2326313
Type:
Small organic molecule
Emp. Form.:
C16H24N4O12
Mol. Mass.:
464.3814
SMILES:
OC[C@H]1O[C@H](OC[C@@H](O)[C@@H](O)[C@H](O)Cn2c3[nH]c(=O)[nH]c(=O)c3[nH]c2=O)[C@H](O)[C@@H](O)[C@H]1O |r|
Structure:
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