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Target
Acid ceramidase
Ligand
BDBM50431255
Substrate
n/a
Meas. Tech.
ChEMBL_949261 (CHEMBL2346137)
IC50
7.0±n/a nM
Citation
 Pizzirani, D; Pagliuca, C; Realini, N; Branduardi, D; Bottegoni, G; Mor, M; Bertozzi, F; Scarpelli, R; Piomelli, D; Bandiera, T Discovery of a new class of highly potent inhibitors of acid ceramidase: synthesis and structure-activity relationship (SAR). J Med Chem 56:3518-30 (2013) [PubMed]  Article 
Target
Name:
Acid ceramidase
Synonyms:
AC | ACDase | ASAH1_RAT | Acid CDase | Acid ceramidase | Acid ceramidase (AC) | Acylsphingosine deacylase | Asah1 | N-acylsphingosine amidohydrolase
Type:
Enzyme
Mol. Mass.:
44450.22
Organism:
Rattus norvegicus (Rat)
Description:
Q6P7S1
Residue:
394
Sequence:
MLGRSLLTWVLAAAVTCAQAQQVPPWTEDCRKSTYPPSGPTYRGPVPWYTINLDLPPYKRWHELLAHKAPVLRTLVNSISNLVNAFVPSGKIMQMVDEKLPGLIGSIPGPFGEEMRGIADVTGIPLGEIISFNIFYELFTMCTSIITEDGKGHLLHGRNMDFGIFLGWNINNNTWVVTEELKPLTVNLDFQRNNKTVFKATSFAGYVGMLTGFKPGLLSLTLNERFSLNGGYLGILEWMFGKKNAQWVGFITRSVLENSTSYEEAKNILTKTKITAPAYFILGGNQSGEGCVITRERKESLDVYELDPKHGRWYVVQTNYDRWKNTLFLDDRRTPAKKCLNHTTQKNLSFATIYDVLSTKPVLNKLTVFTTLIDVTKDQFESHLRDCPDPCIGW
  
Inhibitor
Name:
BDBM50431255
Synonyms:
CHEMBL2333053
Type:
Small organic molecule
Emp. Form.:
C13H18FN3O5
Mol. Mass.:
315.2975
SMILES:
CCCCCCNC(=O)n1cc(F)c(=O)n(C(=O)OC)c1=O
Structure:
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