Target
Acid ceramidase
Ligand
BDBM50431261
Substrate
n/a
Meas. Tech.
ChEMBL_949261 (CHEMBL2346137)
IC50
3400±n/a nM
Citation
 Pizzirani, DPagliuca, CRealini, NBranduardi, DBottegoni, GMor, MBertozzi, FScarpelli, RPiomelli, DBandiera, T Discovery of a new class of highly potent inhibitors of acid ceramidase: synthesis and structure-activity relationship (SAR). J Med Chem 56:3518-30 (2013) [PubMed]  Article 
Target
Name:
Acid ceramidase
Synonyms:
AC | ACDase | ASAH1_RAT | Acid CDase | Acid ceramidase | Acid ceramidase (AC) | Acylsphingosine deacylase | Asah1 | N-acylsphingosine amidohydrolase
Type:
Enzyme
Mol. Mass.:
44450.22
Organism:
Rattus norvegicus (Rat)
Description:
Q6P7S1
Residue:
394
Sequence:
MLGRSLLTWVLAAAVTCAQAQQVPPWTEDCRKSTYPPSGPTYRGPVPWYTINLDLPPYKRWHELLAHKAPVLRTLVNSISNLVNAFVPSGKIMQMVDEKLPGLIGSIPGPFGEEMRGIADVTGIPLGEIISFNIFYELFTMCTSIITEDGKGHLLHGRNMDFGIFLGWNINNNTWVVTEELKPLTVNLDFQRNNKTVFKATSFAGYVGMLTGFKPGLLSLTLNERFSLNGGYLGILEWMFGKKNAQWVGFITRSVLENSTSYEEAKNILTKTKITAPAYFILGGNQSGEGCVITRERKESLDVYELDPKHGRWYVVQTNYDRWKNTLFLDDRRTPAKKCLNHTTQKNLSFATIYDVLSTKPVLNKLTVFTTLIDVTKDQFESHLRDCPDPCIGW
  
Inhibitor
Name:
BDBM50431261
Synonyms:
CHEMBL2333044 | US9428465, 11
Type:
Small organic molecule
Emp. Form.:
C12H20N4O3
Mol. Mass.:
268.3122
SMILES:
CCCCCCNC(=O)n1cc(NC)c(=O)[nH]c1=O
Structure:
Search PDB for entries with ligand similarity: