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Target
Cathepsin D
Ligand
BDBM50432522
Substrate
n/a
Meas. Tech.
ChEMBL_954242 (CHEMBL2352017)
IC50
420±n/a nM
Citation
 Hunt, KW; Cook, AW; Watts, RJ; Clark, CT; Vigers, G; Smith, D; Metcalf, AT; Gunawardana, IW; Burkard, M; Cox, AA; Geck Do, MK; Dutcher, D; Thomas, AA; Rana, S; Kallan, NC; DeLisle, RK; Rizzi, JP; Regal, K; Sammond, D; Groneberg, R; Siu, M; Purkey, H; Lyssikatos, JP; Marlow, A; Liu, X; Tang, TP Spirocyclicß-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloidß in a higher species. J Med Chem 56:3379-403 (2013) [PubMed]  Article 
Target
Name:
Cathepsin D
Synonyms:
CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor
Type:
Enzyme
Mol. Mass.:
44551.72
Organism:
Homo sapiens (Human)
Description:
Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.
Residue:
412
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
  
Inhibitor
Name:
BDBM50432522
Synonyms:
CHEMBL2349484
Type:
Small organic molecule
Emp. Form.:
C21H19ClF3N3O2
Mol. Mass.:
437.843
SMILES:
CC1(C)CC2(N=C(N)N(CC(F)(F)F)C2=O)c2cc(ccc2O1)-c1cccc(Cl)c1 |t:5|
Structure:
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