Target
Cathepsin D
Ligand
BDBM50432497
Substrate
n/a
Meas. Tech.
ChEMBL_954242 (CHEMBL2352017)
IC50
265±n/a nM
Citation
 Hunt, KWCook, AWWatts, RJClark, CTVigers, GSmith, DMetcalf, ATGunawardana, IWBurkard, MCox, AAGeck Do, MKDutcher, DThomas, AARana, SKallan, NCDeLisle, RKRizzi, JPRegal, KSammond, DGroneberg, RSiu, MPurkey, HLyssikatos, JPMarlow, ALiu, XTang, TP Spirocyclicß-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloidß in a higher species. J Med Chem 56:3379-403 (2013) [PubMed]  Article 
Target
Name:
Cathepsin D
Synonyms:
CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor
Type:
Enzyme
Mol. Mass.:
44551.72
Organism:
Homo sapiens (Human)
Description:
Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.
Residue:
412
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
  
Inhibitor
Name:
BDBM50432497
Synonyms:
CHEMBL2349491
Type:
Small organic molecule
Emp. Form.:
C20H19ClFN3O2
Mol. Mass.:
387.835
SMILES:
CN1C(N)=NC2(CC(C)(C)Oc3ccc(cc23)-c2cc(Cl)ccc2F)C1=O |c:3|
Structure:
Search PDB for entries with ligand similarity: