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TargetCathepsin D
LigandBDBM50432506
Substrate/Competitorn/a
Meas. Tech.ChEMBL_954242
IC50 735±n/a nM
Citation Hunt, KWCook, AWWatts, RJClark, CTVigers, GSmith, DMetcalf, ATGunawardana, IWBurkard, MCox, AAGeck Do, MKDutcher, DThomas, AARana, SKallan, NCDeLisle, RKRizzi, JPRegal, KSammond, DGroneberg, RSiu, MPurkey, HLyssikatos, JPMarlow, ALiu, XTang, TP Spirocyclicß-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloidß in a higher species. J Med Chem56:3379-403 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin D
Name:Cathepsin D
Synonyms:Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor
Type:Enzyme
Mol. Mass.:44551.72
Organism:Homo sapiens (Human)
Description:Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.
Residue:412
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP
AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH
HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG
EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ
PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL
MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ
AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50432506
NameBDBM50432506
Synonyms:CHEMBL2349612
TypeSmall organic molecule
Emp. Form.C20H20ClN3O2
Mol. Mass.369.845
SMILESCN1C(N)=NC2(CC(C)(C)Oc3ccc(cc23)-c2cccc(Cl)c2)C1=O |c:3|
Structure
n/a