Target
Bifunctional epoxide hydrolase 2
Ligand
BDBM50435764
Substrate
n/a
Meas. Tech.
ChEMBL_965763 (CHEMBL2393702)
IC50
2.0±n/a nM
Citation
 Thalji, RKMcAtee, JJBelyanskaya, SBrandt, MBrown, GDCostell, MHDing, YDodson, JWEisennagel, SHFries, REGross, JWHarpel, MRHolt, DAIsrael, DIJolivette, LJKrosky, DLi, HLu, QMandichak, TRoethke, TSchnackenberg, CGSchwartz, BShewchuk, LMXie, WBehm, DJDouglas, SAShaw, ALMarino, JP Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett 23:3584-8 (2013) [PubMed]  Article 
Target
Name:
Bifunctional epoxide hydrolase 2
Synonyms:
Ephx2 | Epoxide hydrolase 2 | HYES_RAT
Type:
PROTEIN
Mol. Mass.:
62337.15
Organism:
Rattus norvegicus
Description:
ChEMBL_1465995
Residue:
554
Sequence:
MALRVAAFDLDGVLALPSIAGVLRHTEEALALPRDFLLGAFQMKFPEGPTEQLMKGKITFSQWVPLMDESCRKSSKACGASLPENFSISEIFSQAMAARSINRPMLQAAAALKKKGFTTCIVTNNWLDDSDKRDILAQMMCELSQHFDFLIESCQVGMIKPEPQIYKFVLDTLKAKPNEVVFLDDFGSNLKPARDMGMVTILVRDTASALRELEKVTGTQFPEAPLPVPCSPNDVSHGYVTVKPGIRLHFVEMGSGPAICLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSPPEIEEYAMELLCEEMVTFLNKLGIPQAVFIGHDWAGVLVWNMALFHPERVRAVASLNTPLMPPNPEVSPMEVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRTSDDMGLLTVNKATEMGGILVGTPEDPKVSKITTEEEIEYYIQQFKKSGFRGPLNWYRNTERNWKWSCKALGRKILVPALMVTAEKDIVLRPEMSKNMENWIPFLKRGHIEDCGHWTQIEKPAEVNQILIKWLKTEIQNPSVTSKI
  
Inhibitor
Name:
BDBM50435764
Synonyms:
CHEMBL2392692
Type:
Small organic molecule
Emp. Form.:
C19H22BrF3N6O2
Mol. Mass.:
503.316
SMILES:
CNc1nc(C)nc(n1)N1CCC(CC1)C(=O)NCc1ccc(Br)cc1OC(F)(F)F
Structure:
Search PDB for entries with ligand similarity: