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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM50437932
Substrate
n/a
Meas. Tech.
ChEMBL_972806 (CHEMBL2411274)
Ki
21000±n/a nM
Citation
 al-Rashida, M; Raza, R; Abbas, G; Shah, MS; Kostakis, GE; Lecka, J; Sévigny, J; Muddassar, M; Papatriantafyllopoulou, C; Iqbal, J Identification of novel chromone based sulfonamides as highly potent and selective inhibitors of alkaline phosphatases. Eur J Med Chem 66:438-49 (2013) [PubMed]  Article 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | AP-TNAP | Alkaline phosphatase liver/bone/kidney isozyme | Alkaline phosphatase, tissue-nonspecific isozyme | PPBT_BOVIN | TNSALP | Tissue non-specific alkaline phosphatase (TNAP)
Type:
Protein
Mol. Mass.:
57195.60
Organism:
Bos taurus (Cattle)
Description:
P09487
Residue:
524
Sequence:
MISPFLLLAIGTCFASSLVPEKEKDPKYWRDQAQQTLKNALRLQTLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHSPGEETKLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIKDIEVIMGGGRKYMFPKNRTDVEYELDEKARGTRLDGLNLIDIWKSFKPKHKHSHYVWNRTDLLALDPHSVDYLLGLFEPGDMQYELNRNNATDPSLSEMVEMAIRILNKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIGQAGAMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAACIGANRDHCASASSSGSPSPGPLLLLLALLPLGSLF
  
Inhibitor
Name:
BDBM50437932
Synonyms:
CHEMBL2408704
Type:
Small organic molecule
Emp. Form.:
C21H19FN4O5S2
Mol. Mass.:
490.528
SMILES:
CCOC1Oc2ccc(F)cc2C(=O)C1=CNc1ccc(cc1)S(=O)(=O)Nc1nnc(C)s1 |w:15.17|
Structure:
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