Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50386955
Substrate
n/a
Meas. Tech.
ChEMBL_982013 (CHEMBL2428368)
Ki
269±n/a nM
Citation
 McClure, KFJackson, MCameron, KOKung, DWPerry, DAOrr, STZhang, YKohrt, JTu, MGao, HFernando, DJones, RErasga, NWang, GPolivkova, JJiao, WSwartz, RUeno, HBhattacharya, SKStock, IAVarma, SBagdasarian, VPerez, SKelly-Sullivan, DWang, RKong, JCornelius, PMichael, LLee, EJanssen, ASteyn, SJLapham, KGoosen, T Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor. Bioorg Med Chem Lett 23:5410-4 (2013) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:
GPCR
Mol. Mass.:
51730.61
Organism:
Homo sapiens (Human)
Description:
P08172
Residue:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50386955
Synonyms:
CHEMBL2048820
Type:
Small organic molecule
Emp. Form.:
C24H26ClN7OS
Mol. Mass.:
496.028
SMILES:
Cc1cn2cc(CC(=O)N3CCC4(CN(Cc5ccc(cc5Cl)-n5nccn5)C4)CC3)nc2s1
Structure:
Search PDB for entries with ligand similarity: