Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50440264
Substrate
n/a
Meas. Tech.
ChEMBL_982014 (CHEMBL2428369)
Ki
1380±n/a nM
Citation
 McClure, KFJackson, MCameron, KOKung, DWPerry, DAOrr, STZhang, YKohrt, JTu, MGao, HFernando, DJones, RErasga, NWang, GPolivkova, JJiao, WSwartz, RUeno, HBhattacharya, SKStock, IAVarma, SBagdasarian, VPerez, SKelly-Sullivan, DWang, RKong, JCornelius, PMichael, LLee, EJanssen, ASteyn, SJLapham, KGoosen, T Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor. Bioorg Med Chem Lett 23:5410-4 (2013) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50440264
Synonyms:
CHEMBL2426682
Type:
Small organic molecule
Emp. Form.:
C27H30N4O2S
Mol. Mass.:
474.618
SMILES:
COc1ccc(CC(=O)N2CCC3(CN(C3)[C@H]3CCc4cc(ccc34)-c3nccs3)CC2)nc1 |r|
Structure:
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