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Target
3-oxoacyl-[acyl-carrier-protein] reductase
Ligand
BDBM50440622
Substrate
n/a
Meas. Tech.
ChEMBL_983602 (CHEMBL2427114)
IC50
>100000±n/a nM
Citation
 Belluti, F; Perozzo, R; Lauciello, L; Colizzi, F; Kostrewa, D; Bisi, A; Gobbi, S; Rampa, A; Bolognesi, ML; Recanatini, M; Brun, R; Scapozza, L; Cavalli, A Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of Plasmodium falciparum enoyl-ACP-reductase (PfFabI). J Med Chem 56:7516-26 (2013) [PubMed]  Article 
Target
Name:
3-oxoacyl-[acyl-carrier-protein] reductase
Synonyms:
3-oxoacyl-(Acyl-carrier protein) reductase | FabG
Type:
PROTEIN
Mol. Mass.:
33360.55
Organism:
Plasmodium falciparum (isolate 3D7)
Description:
ChEMBL_107660
Residue:
301
Sequence:
MSVLHRFYLFFLFTKFFHCYKISYVLKNAKLAPNHAIKNINSLNLLSENKKENYYYCGENKVALVTGAGRGIGREIAKMLAKSVSHVICISRTQKSCDSVVDEIKSFGYESSGYAGDVSKKEEISEVINKILTEHKNVDILVNNAGITRDNLFLRMKNDEWEDVLRTNLNSLFYITQPISKRMINNRYGRIINISSIVGLTGNVGQANYSSSKAGVIGFTKSLAKELASRNITVNAIAPGFISSDMTDKISEQIKKNIISNIPAGRMGTPEEVANLACFLSSDKSGYINGRVFVIDGGLSP
  
Inhibitor
Name:
BDBM50440622
Synonyms:
CHEMBL2426556
Type:
Small organic molecule
Emp. Form.:
C21H13ClO5
Mol. Mass.:
380.778
SMILES:
Oc1ccc2cc(-c3ccc(Oc4ccc(Cl)cc4O)cc3)c(=O)oc2c1
Structure:
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