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Target
Signal peptidase IB
Ligand
BDBM50441139
Substrate
n/a
Meas. Tech.
ChEMBL_984215 (CHEMBL2432375)
IC50
1800±n/a nM
Citation
 Liu, J; Smith, PA; Steed, DB; Romesberg, F Efforts toward broadening the spectrum of arylomycin antibiotic activity. Bioorg Med Chem Lett 23:5654-9 (2013) [PubMed]  Article 
Target
Name:
Signal peptidase IB
Synonyms:
LEP_STAAU | Leader peptidase IB | SPase IB | spsB
Type:
PROTEIN
Mol. Mass.:
21697.12
Organism:
Staphylococcus aureus
Description:
ChEMBL_107663
Residue:
191
Sequence:
MKKELLEWIISIAVAFVILFIVGKFIVTPYTIKGESMDPTLKDGERVAVNIIGYKTGGLEKGNVVVFHANKNDDYVKRVIGVPGDKVEYKNDTLYVNGKKQDEPYLNYNLKHKQGDYITGTFQVKDLPNANPKSNVIPKGKYLVLGDNREVSKDSRAFGLIDEDQIVGKVSFRFWPFSEFKHNFNPENTKN
  
Inhibitor
Name:
BDBM50441139
Synonyms:
ARYLOMYCIN C16
Type:
Small organic molecule
Emp. Form.:
C46H68N6O11
Mol. Mass.:
881.0657
SMILES:
CCCCCCCCCCCCCCCC(=O)N(C)[C@H](CO)C(=O)N[C@H](C)C(=O)NCC(=O)N(C)[C@H]1c2ccc(O)c(c2)-c2cc(C[C@H](NC(=O)[C@H](C)NC1=O)C(O)=O)ccc2O |r|
Structure:
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