Target
Alkaline phosphatase, placental type
Ligand
BDBM76215
Substrate
n/a
Meas. Tech.
ChEMBL_1288274 (CHEMBL3117348)
IC50
>100000±n/a nM
Citation
 Ardecky, RJBobkova, EVKiffer-Moreira, TBrown, BGanji, SZou, JPass, INarisawa, SIano, FGRosenstein, CCheltsov, ARascon, JHedrick, MGasior, CForster, AShi, SDahl, RVasile, SSu, YSergienko, EChung, TDKaunitz, JHoylaerts, MFPinkerton, ABMillán, JL Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes. Bioorg Med Chem Lett 24:1000-4 (2014) [PubMed]  Article 
Target
Name:
Alkaline phosphatase, placental type
Synonyms:
ALPP | Alkaline phosphatase placental type | PLAP | PPB1_HUMAN
Type:
PROTEIN
Mol. Mass.:
57950.65
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1506090
Residue:
535
Sequence:
MLGPCMLLLLLLLGLRLQLSLGIIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAGTTDAAHPGRSVVPALLPLLAGTLLLLETATAP
  
Inhibitor
Name:
BDBM76215
Synonyms:
CHEMBL1349252 | MLS001096095 | N-(3-cyanophenyl)-3-[(2-keto-3H-1,3-benzoxazol-6-yl)sulfonylamino]propionamide | N-(3-cyanophenyl)-3-[(2-oxidanylidene-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide | N-(3-cyanophenyl)-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide | SMR000631049 | cid_24790981
Type:
Small organic molecule
Emp. Form.:
C17H14N4O5S
Mol. Mass.:
386.382
SMILES:
O=C(CCNS(=O)(=O)c1ccc2[nH]c(=O)oc2c1)Nc1cccc(c1)C#N
Structure:
Search PDB for entries with ligand similarity: