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Reaction Details
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TargetPregnane X receptor
LigandBDBM50448128
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1291943
EC50 18000±n/a nM
Citation Sepe, VD'Amore, CUmmarino, RRenga, BD'Auria, MVNovellino, ESinisi, ATaglialatela-Scafati, ONakao, YLimongelli, VZampella, AFiorucci, S Insights on pregnane-X-receptor modulation. Natural and semisynthetic steroids from Theonella marine sponges. Eur J Med Chem73:126-34 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Pregnane X receptor
Name:Pregnane X receptor
Synonyms:NR1I2 | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1
Type:Nuclear receptor
Mol. Mass.:49774.77
Organism:Homo sapiens (Human)
Description:O75469
Residue:434
Sequence:
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG
CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE
RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSS
GCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL
PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE
CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR
VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF
ATPLMQELFGITGS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50448128
NameBDBM50448128
Synonyms:CHEMBL3122141
TypeSmall organic molecule
Emp. Form.C29H50O
Mol. Mass.414.7067
SMILESCC(C)[C@H](C)CC[C@@H](C)[C@H]1CCC2=C3CC[C@H]4[C@H](C)[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C |r,c:12|
Structure
n/a