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Target
Beta-3 adrenergic receptor
Ligand
BDBM50002605
Substrate
n/a
Meas. Tech.
ChEMBL_352666 (CHEMBL862145)
EC50
0.20±n/a nM
Citation
 Uehling, DE; Shearer, BG; Donaldson, KH; Chao, EY; Deaton, DN; Adkison, KK; Brown, KK; Cariello, NF; Faison, WL; Lancaster, ME; Lin, J; Hart, R; Milliken, TO; Paulik, MA; Sherman, BW; Sugg, EE; Cowan, C Biarylaniline phenethanolamines as potent and selective beta3 adrenergic receptor agonists. J Med Chem 49:2758-71 (2006) [PubMed]  Article 
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43534.88
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
  
Inhibitor
Name:
BDBM50002605
Synonyms:
CHEMBL206002
Type:
Small organic molecule
Emp. Form.:
C25H25ClN2O5
Mol. Mass.:
468.929
SMILES:
C[C@H](CNc1cccc(c1)-c1ccc(cc1C(O)=O)C(O)=O)NC[C@H](O)c1cccc(Cl)c1
Structure:
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