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Target
Ubiquitin carboxyl-terminal hydrolase 8
Ligand
BDBM50007791
Substrate
n/a
Meas. Tech.
ChEMBL_1335826 (CHEMBL3239935)
IC50
>100000±n/a nM
Citation
 Báez-Santos, YM; Barraza, SJ; Wilson, MW; Agius, MP; Mielech, AM; Davis, NM; Baker, SC; Larsen, SD; Mesecar, AD X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases. J Med Chem 57:2393-412 (2014) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 8
Synonyms:
Deubiquitinating enzyme 8 | KIAA0055 | UBP8_HUMAN | UBPY | USP8 | Ubiquitin isopeptidase Y | Ubiquitin thioesterase 8 | Ubiquitin-specific-processing protease 8 | hUBPy
Type:
PROTEIN
Mol. Mass.:
127547.92
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105200
Residue:
1118
Sequence:
MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIFKTAEECRLDRDEERAYVLYMKYVTVYNLIKKRPDFKQQQDYFHSILGPGNIKKAVEEAERLSESLKLRYEEAEVRKKLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEKGAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLPDDSKDTWKKRGNVEYVVLLDWFSSAKDLQIGTTLRSLKDALFKWESKTVLRNEPLVLEGGYENWLLCYPQYTTNAKVTPPPRRQNEEVSISLDFTYPSLEESIPSKPAAQTPPASIEVDENIELISGQNERMGPLNISTPVEPVAASKSDVSPIIQPVPSIKNVPQIDRTKKPAVKLPEEHRIKSESTNHEQQSPQSGKVIPDRSTKPVVFSPTLMLTDEEKARIHAETALLMEKNKQEKELRERQQEEQKEKLRKEEQEQKAKKKQEAEENEITEKQQKAKEEMEKKESEQAKKEDKETSAKRGKEITGVKRQSKSEHETSDAKKSVEDRGKRCPTPEIQKKSTGDVPHTSVTGDSGSGKPFKIKGQPESGILRTGTFREDTDDTERNKAQREPLTRARSEEMGRIVPGLPSGWAKFLDPITGTFRYYHSPTNTVHMYPPEMAPSSAPPSTPPTHKAKPQIPAERDREPSKLKRSYSSPDITQAIQEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFYTSLGPRVTDVAT
  
Inhibitor
Name:
BDBM50007791
Synonyms:
CHEMBL3233815 | med.21724, Compound 168
Type:
Small organic molecule
Emp. Form.:
C25H27FN2O
Mol. Mass.:
390.4931
SMILES:
C[C@@H](N1CCC(CC1)C(=O)NCc1cccc(F)c1)c1cccc2ccccc12 |r|
Structure:
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