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TargetUbiquitin carboxyl-terminal hydrolase 20
LigandBDBM50007791
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1335827
IC50>100000±n/a nM
Citation BŠez-Santos, YMBarraza, SJWilson, MWAgius, MPMielech, AMDavis, NMBaker, SCLarsen, SDMesecar, AD X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases. J Med Chem57:2393-412 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Ubiquitin carboxyl-terminal hydrolase 20
Name:Ubiquitin carboxyl-terminal hydrolase 20
Synonyms:Deubiquitinating enzyme 20 | KIAA1003 | LSFR3A | USP20 | Ubiquitin thioesterase 20 | Ubiquitin-specific-processing protease 20 | VDU2 | VHL-interacting deubiquitinating enzyme 2 | hVDU2
Type:PROTEIN
Mol. Mass.:101993.90
Organism:Homo sapiens (Human)
Description:ChEMBL_108270
Residue:914
Sequence:
MGDSRDLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADH
STIHAQAKKHNLTVNLTTFRLWCYACEKEVFLEQRLAAPLLGSSSKFSEQDSPPPSHPLK
AVPIAVADEGESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLV
RTDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLM
DQLHEELKEPVVATVALTEARDSDSSDTDEKREGDRSPSEDEFLSCDSSSDRGEGDGQGR
GGGSSQAETELLIPDEAGRAISEKERMKDRKFSWGQQRTNSEQVDEDADVDTAMAALDDQ
PAEAQPPSPRSSSPCRTPEPDNDAHLRSSSRPCSPVHHHEGHAKLSSSPPRASPVRMAPS
YVLKKAQVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIP
GKEDLAKLHSAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLE
DCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKIN
SHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFD
DQYVTEVHETVVQNAEGYVLFYRKSSEEAMRERQQVVSLAAMREPSLLRFYVSREWLNKF
NTFAEPGPITNQTFLCSHGGIPPHKYHYIDDLVVILPQNVWEHLYNRFGGGPAVNHLYVC
SICQVEIEALAKRRRIEIDTFIKLNKAFQAEESPGVIYCISMQWFREWEAFVKGKDNEPP
GPIDNSRIAQVKGSGHVQLKQGADYGQISEETWTYLNSLYGGGPEIAIRQSVAQPLGPEN
LHGEQKIEAETRAV
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  Blast E-value cutoff:
BDBM50007791
NameBDBM50007791
Synonyms:CHEMBL3233815 | med.21724, Compound 168
TypeSmall organic molecule
Emp. Form.C25H27FN2O
Mol. Mass.390.4931
SMILESC[C@@H](N1CCC(CC1)C(=O)NCc1cccc(F)c1)c1cccc2ccccc12 |r|
Structure
n/a