Target
Polyunsaturated fatty acid lipoxygenase ALOX15B
Ligand
BDBM79800
Substrate
n/a
Meas. Tech.
ChEMBL_1352304 (CHEMBL3269368)
IC50
>50000±n/a nM
Citation
 Rai, GJoshi, NJung, JELiu, YSchultz, LYasgar, APerry, SDiaz, GZhang, QKenyon, VJadhav, ASimeonov, ALo, EHvan Leyen, KMaloney, DJHolman, TR Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. J Med Chem 57:4035-48 (2014) [PubMed]  Article 
Target
Name:
Polyunsaturated fatty acid lipoxygenase ALOX15B
Synonyms:
15-LOX-2 | 15-Lipo-oxygenase type 2 (15-LOX-2) | 15-Lipoxygenase-2 (15-LOX-2) | 15-lipoxygenase 2 | ALOX15B | Arachidonate 15-lipoxygenase type II | Arachidonate 15-lipoxygenase, type II | Arachidonate 15-lipoxygenase-2 | Epithelial 15-lipoxygenase-2 | LX15B_HUMAN
Type:
Protein
Mol. Mass.:
75850.40
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
676
Sequence:
MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPEDVGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGGHLLFPCYQWLEGAGTLVLQEGTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPHCLDEKTVEDLELNIKYSTAKNANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAAEHAFEHWQEDAFFASQFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTSLQAELEKGSLFLVDHGILSGIQTNVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLSQTPGPNSPIFLPTDDKWDWLLAKTWVRNAEFSFHEALTHLLHSHLLPEVFTLATLRQLPHCHPLFKLLIPHTRYTLHINTLARELLIVPGQVVDRSTGIGIEGFSELIQRNMKQLNYSLLCLPEDIRTRGVEDIPGYYYRDDGMQIWGAVERFVSEIIGIYYPSDESVQDDRELQAWVREIFSKGFLNQESSGIPSSLETREALVQYVTMVIFTCSAKHAAVSAGQFDSCAWMPNLPPSMQLPPPTSKGLATCEGFIATLPPVNATCDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPRRSIATFQSRLAQISRGIQERNQGLVLPYTYLDPPLIENSVSI
  
Inhibitor
Name:
BDBM79800
Synonyms:
5-(methylamino)-2-(1-naphthalenyl)-4-oxazolecarbonitrile | 5-(methylamino)-2-(1-naphthyl)oxazole-4-carbonitrile | 5-(methylamino)-2-naphthalen-1-yl-1,3-oxazole-4-carbonitrile | MLS000082299 | SMR000045344 | cid_664510
Type:
Small organic molecule
Emp. Form.:
C15H11N3O
Mol. Mass.:
249.2673
SMILES:
CNc1oc(nc1C#N)-c1cccc2ccccc12
Structure:
Search PDB for entries with ligand similarity: