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Target
Macrophage migration inhibitory factor
Ligand
BDBM50013032
Substrate
n/a
Meas. Tech.
ChEMBL_1351718 (CHEMBL3270118)
IC50
550±n/a nM
Citation
 Xu, L; Zhang, Y; Zheng, L; Qiao, C; Li, Y; Li, D; Zhen, X; Hou, T Discovery of novel inhibitors targeting the macrophage migration inhibitory factor via structure-based virtual screening and bioassays. J Med Chem 57:3737-45 (2014) [PubMed]  Article 
Target
Name:
Macrophage migration inhibitory factor
Synonyms:
GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase
Type:
Enzyme
Mol. Mass.:
12478.18
Organism:
Homo sapiens (Human)
Description:
P14174
Residue:
115
Sequence:
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
  
Inhibitor
Name:
BDBM50013032
Synonyms:
CHEMBL1604170
Type:
Small organic molecule
Emp. Form.:
C21H16N2O3S
Mol. Mass.:
376.428
SMILES:
OC(=O)c1cccc(NC(=S)NC(=O)c2ccc(cc2)-c2ccccc2)c1
Structure:
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