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TargetRuvB-like 1
LigandBDBM50015299
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1349809
IC50 9000±n/a nM
Citation Elkaim, JLamblin, MLaguerre, MRosenbaum, JLestienne, PEloy, LCresteil, TFelpin, FXDessolin, J Design, synthesis and biological evaluation of Pontin ATPase inhibitors through a molecular docking approach. Bioorg Med Chem Lett24:2512-6 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
RuvB-like 1
Name:RuvB-like 1
Synonyms:49 kDa TATA box-binding protein-interacting protein | 49 kDa TBP-interacting protein | 54 kDa erythrocyte cytosolic protein | ECP-54 | INO80 complex subunit H | INO80H | NMP 238 | NMP238 | Nuclear matrix protein 238 | Pontin 52 | RUVBL1 | TAP54-alpha | TIP49 | TIP49A | TIP49a | TIP60-associated protein 54-alpha
Type:PROTEIN
Mol. Mass.:50226.43
Organism:Homo sapiens (Human)
Description:ChEMBL_108308
Residue:456
Sequence:
MKIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENAREACGVIVELIKSKK
MAGRAVLLAGPPGTGKTALALAIAQELGSKVPFCPMVGSEVYSTEIKKTEVLMENFRRAI
GLRIKETKEVYEGEVTELTPCETENPMGGYGKTISHVIIGLKTAKGTKQLKLDPSIFESL
QKERVEAGDVIYIEANSGAVKRQGRCDTYATEFDLEAEEYVPLPKGDVHKKKEIIQDVTL
HDLDVANARPQGGQDILSMMGQLMKPKKTEITDKLRGEINKVVNKYIDQGIAELVPGVLF
VDEVHMLDIECFTYLHRALESSIAPIVIFASNRGNCVIRGTEDITSPHGIPLDLLDRVMI
IRTMLYTPQEMKQIIKIRAQTEGINISEEALNHLGEIGTKTTLRYSVQLLTPANLLAKIN
GKDSIEKEHVEEISELFYDAKSSAKILADQQDKYMK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50015299
NameBDBM50015299
Synonyms:CHEMBL3263107
TypeSmall organic molecule
Emp. Form.C28H24N4O3
Mol. Mass.464.5152
SMILESN[C@@H](Cc1c[nH]c2ccccc12)C(=O)Nc1ccc(cc1)-c1c(O)c(c[nH]c1=O)-c1ccccc1 |r|
Structure
n/a