Reaction Details Report a problem with these data
Target
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Ligand
BDBM50019859
Substrate
n/a
Meas. Tech.
ChEMBL_1361547 (CHEMBL3294871)
Kd
16±n/a nM
Citation
 Zimmermann, G; Schultz-Fademrecht, C; Küchler, P; Murarka, S; Ismail, S; Triola, G; Nussbaumer, P; Wittinghofer, A; Waldmann, H Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEd prenyl binding site. J Med Chem 57:5435-48 (2014) [PubMed]  Article 
Target
Name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Synonyms:
3',5'-cyclic phosphodiesterase | GMP-PDE delta | PDE6D | PDE6D_HUMAN | PDED | Protein p17 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Type:
PROTEIN
Mol. Mass.:
17418.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105761
Residue:
150
Sequence:
MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV
  
Inhibitor
Name:
BDBM50019859
Synonyms:
CHEMBL3286923
Type:
Small organic molecule
Emp. Form.:
C37H42FN3O5
Mol. Mass.:
627.7449
SMILES:
CC(C)c1c(C(=O)Nc2ccccc2)c(c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC(=O)N1CCOCC1)-c1ccccc1 |r|
Structure:
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