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Target
DNA polymerase subunit gamma-1
Ligand
BDBM50021053
Substrate
n/a
Meas. Tech.
ChEMBL_1365495 (CHEMBL3297010)
IC50
>100000±n/a nM
Citation
 Draffan, AG; Frey, B; Pool, B; Gannon, C; Tyndall, EM; Lilly, M; Francom, P; Hufton, R; Halim, R; Jahangiri, S; Bond, S; Nguyen, VT; Jeynes, TP; Wirth, V; Luttick, A; Tilmanis, D; Thomas, JD; Pryor, M; Porter, K; Morton, CJ; Lin, B; Duan, J; Kukolj, G; Simoneau, B; McKercher, G; Lagacé, L; Amad, M; Bethell, RC; Tucker, SP Discovery and Synthesis of C-Nucleosides as Potential New Anti-HCV Agents. ACS Med Chem Lett 5:679-84 (2014) [PubMed]  Article 
Target
Name:
DNA polymerase subunit gamma-1
Synonyms:
DNA Polymerase gamma | DNA nucleotidylexotransferase | DNA polymerase (alpha/delta/epsilon) | DNA polymerase beta | DNA polymerase delta subunit 1 | DNA polymerase eta | DNA polymerase gamma subunit 1 | DNA polymerase iota | DNA polymerase kappa | DNA polymerase lambda | DNA polymerase subunit gamma-1 | DNA-directed DNA/RNA polymerase mu | DPOG1_HUMAN | MDP1 | Mitochondrial DNA polymerase catalytic subunit | POLG | POLG1 | POLGA | PolG-alpha
Type:
Enzyme Subunit
Mol. Mass.:
139566.98
Organism:
Homo sapiens (Human)
Description:
Enzyme was purchased from Ulrich Hubscher, University of Zurich-Irchel, Switzerland.
Residue:
1239
Sequence:
MSRLLWRKVAGATVGPGPVPAPGRWVSSSVPASDPSDGQRRRQQQQQQQQQQQQQPQQPQVLSSEGGQLRHNPLDIQMLSRGLHEQIFGQGGEMPGEAAVRRSVEHLQKHGLWGQPAVPLPDVELRLPPLYGDNLDQHFRLLAQKQSLPYLEAANLLLQAQLPPKPPAWAWAEGWTRYGPEGEAVPVAIPEERALVFDVEVCLAEGTCPTLAVAISPSAWYSWCSQRLVEERYSWTSQLSPADLIPLEVPTGASSPTQRDWQEQLVVGHNVSFDRAHIREQYLIQGSRMRFLDTMSMHMAISGLSSFQRSLWIAAKQGKHKVQPPTKQGQKSQRKARRGPAISSWDWLDISSVNSLAEVHRLYVGGPPLEKEPRELFVKGTMKDIRENFQDLMQYCAQDVWATHEVFQQQLPLFLERCPHPVTLAGMLEMGVSYLPVNQNWERYLAEAQGTYEELQREMKKSLMDLANDACQLLSGERYKEDPWLWDLEWDLQEFKQKKAKKVKKEPATASKLPIEGAGAPGDPMDQEDLGPCSEEEEFQQDVMARACLQKLKGTTELLPKRPQHLPGHPGWYRKLCPRLDDPAWTPGPSLLSLQMRVTPKLMALTWDGFPLHYSERHGWGYLVPGRRDNLAKLPTGTTLESAGVVCPYRAIESLYRKHCLEQGKQQLMPQEAGLAEEFLLTDNSAIWQTVEELDYLEVEAEAKMENLRAAVPGQPLALTARGGPKDTQPSYHHGNGPYNDVDIPGCWFFKLPHKDGNSCNVGSPFAKDFLPKMEDGTLQAGPGGASGPRALEINKMISFWRNAHKRISSQMVVWLPRSALPRAVIRHPDYDEEGLYGAILPQVVTAGTITRRAVEPTWLTASNARPDRVGSELKAMVQAPPGYTLVGADVDSQELWIAAVLGDAHFAGMHGCTAFGWMTLQGRKSRGTDLHSKTATTVGISREHAKIFNYGRIYGAGQPFAERLLMQFNHRLTQQEAAEKAQQMYAATKGLRWYRLSDEGEWLVRELNLPVDRTEGGWISLQDLRKVQRETARKSQWKKWEVVAERAWKGGTESEMFNKLESIATSDIPRTPVLGCCISRALEPSAVQEEFMTSRVNWVVQSSAVDYLHLMLVAMKWLFEEFAIDGRFCISIHDEVRYLVREEDRYRAALALQITNLLTRCMFAYKLGLNDLPQSVAFFSAVDIDRCLRKEVTMDCKTPSNPTGMERRYGIPQGEALDIYQIIELTKGSLEKRSQPGP
  
Inhibitor
Name:
BDBM50021053
Synonyms:
CHEMBL3287609
Type:
Small organic molecule
Emp. Form.:
C12H19N4O13P3
Mol. Mass.:
520.2195
SMILES:
C[C@@]1(O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1c1ccc2c(N)ncnn12 |r|
Structure:
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