Reaction Details Report a problem with these data
Target
Cytosol aminopeptidase [33-68,L62W]
Ligand
BDBM50024594
Substrate
n/a
Meas. Tech.
ChEMBL_1442056 (CHEMBL3373424)
Ki
0.230000±n/a nM
Citation
 Vassiliou, S; Weglarz-Tomczak, E; Berlicki, L; Pawelczak, M; Nocek, B; Mulligan, R; Joachimiak, A; Mucha, A Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases. J Med Chem 57:8140-51 (2014) [PubMed]  Article 
Target
Name:
Cytosol aminopeptidase [33-68,L62W]
Synonyms:
AMPL_PIG | Cytosol aminopeptidase | LAP3 | Leucine aminopeptidase (LAP)
Type:
Enzyme
Mol. Mass.:
4015.44
Organism:
Sus scrofa (Pig)
Description:
P28839[33-68,L62W]
Residue:
36
Sequence:
TKGLVLGIYSKEKEDDAPQFTSAGENFDKWVSGKLR
  
Inhibitor
Name:
BDBM50024594
Synonyms:
(R)-1-Ammonium-3-methyl-butane-1-phosphonic acid anion | CHEMBL40422 | LEUCINE PHOSPHONIC ACID
Type:
Small organic molecule
Emp. Form.:
C5H14NO3P
Mol. Mass.:
167.1433
SMILES:
CC(C)C[C@H]([NH3+])P(O)([O-])=O
Structure:
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