Target
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Ligand
BDBM50027682
Substrate
n/a
Meas. Tech.
ChEMBL_1435384 (CHEMBL3383458)
IC50
140±n/a nM
Citation
 Ferla, SGomaa, MSBrancale, AZhu, JOchalek, JTDeLuca, HFSimons, C Novel styryl-indoles as small molecule inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): Synthesis and biological evaluation. Eur J Med Chem 87:39-51 (2014) [PubMed]  Article 
Target
Name:
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Synonyms:
25-OHD-1 alpha-hydroxylase | 25-hydroxyvitamin D(3) 1-alpha-hydroxylase | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial | CP27B_MOUSE | Calcidiol 1-monooxygenase | Cyp27b | Cyp27b | Cyp27b1 | Cyp40 | Cytochrome P450 subfamily XXVIIB polypeptide 1 | Cytochrome P450C1 alpha | Cytochrome P450VD1-alpha | Cytochrome p450 27B1 | VD3 1A hydroxylase
Type:
PROTEIN
Mol. Mass.:
56238.51
Organism:
Mus musculus
Description:
ChEMBL_109473
Residue:
507
Sequence:
MTQAVKLASRVFHRIHLPLQLDASLGSRGSESVLRSLSDIPGPSTLSFLAELFCKGGLSRLHELQVHGAARYGPIWSGSFGTLRTVYVADPTLVEQLLRQESHCPERCSFSSWAEHRRRHQRACGLLTADGEEWQRLRSLLAPLLLRPQAAAGYAGTLDNVVRDLVRRLRRQRGRGSGLPGLVLDVAGEFYKFGLESIGAVLLGSRLGCLEAEVPPDTETFIHAVGSVFVSTLLTMAMPNWLHHLIPGPWARLCRDWDQMFAFAQRHVELREGEAAMRNQGKPEEDMPSGHHLTHFLFREKVSVQSIVGNVTELLLAGVDTVSNTLSWTLYELSRHPDVQTALHSEITAGTRGSCAHPHGTALSQLPLLKAVIKEVLRLYPVVPGNSRVPDRDIRVGNYVIPQDTLVSLCHYATSRDPTQFPDPNSFNPARWLGEGPTPHPFASLPFGFGKRSCIGRRLAELELQMALSQILTHFEVLPEPGALPIKPMTRTVLVPERSINLQFVDR
  
Inhibitor
Name:
BDBM50027682
Synonyms:
CHEMBL3344393
Type:
Small organic molecule
Emp. Form.:
C24H25N3O2
Mol. Mass.:
387.4742
SMILES:
COc1cc(OC)cc(\C=C\c2cccc3n(CCCn4ccnc4)ccc23)c1
Structure:
Search PDB for entries with ligand similarity: