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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Ligand
BDBM50028926
Substrate
n/a
Meas. Tech.
ChEMBL_1432322 (CHEMBL3383866)
IC50
3000±n/a nM
Citation
 García, AM; Brea, J; Morales-García, JA; Perez, DI; González, A; Alonso-Gil, S; Gracia-Rubio, I; Ros-Simó, C; Conde, S; Cadavid, MI; Loza, MI; Perez-Castillo, A; Valverde, O; Martinez, A; Gil, C Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors. J Med Chem 57:8590-607 (2014) [PubMed]  Article 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Synonyms:
3',5'-cyclic phosphodiesterase | PDE7B | PDE7B_HUMAN | Phosphodiesterase 7B | Phosphodiesterase 7B (PDE7B) | cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Type:
Enzyme
Mol. Mass.:
51842.76
Organism:
Homo sapiens (Human)
Description:
Q9NP56
Residue:
450
Sequence:
MSCLMVERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTYSGEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQHRSRGSSGSGPDHDHAGQGTESEEQEGDSP
  
Inhibitor
Name:
BDBM50028926
Synonyms:
CHEMBL3359624
Type:
Small organic molecule
Emp. Form.:
C12H9ClN2O2S
Mol. Mass.:
280.73
SMILES:
Nc1ccc(Sc2ccc(Cl)cc2[N+]([O-])=O)cc1
Structure:
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