Target
Kinesin-like protein KIFC1
Ligand
BDBM50037969
Substrate
n/a
Meas. Tech.
ChEMBL_1438848 (CHEMBL3390316)
IC50
50000±n/a nM
Citation
 Yang, BLamb, MLZhang, THennessy, EJGrewal, GSha, LZambrowski, MBlock, MHDowling, JESu, NWu, JDeegan, TMikule, KWang, WKaspera, RChuaqui, CChen, H Discovery of potent KIFC1 inhibitors using a method of integrated high-throughput synthesis and screening. J Med Chem 57:9958-70 (2014) [PubMed]  Article 
Target
Name:
Kinesin-like protein KIFC1
Synonyms:
HSET | HSET | KIFC1 | KIFC1_HUMAN | KNSL2 | Kinesin-like protein 2 | Kinesin-like protein KIFC1 | Kinesin-related protein HSET
Type:
PROTEIN
Mol. Mass.:
73763.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109524
Residue:
673
Sequence:
MDPQRSPLLEVKGNIELKRPLIKAPSQLPLSGSRLKRRPDQMEDGLEPEKKRTRGLGATTKITTSHPRVPSLTTVPQTQGQTTAQKVSKKTGPRCSTAIATGLKNQKPVPAVPVQKSGTSGVPPMAGGKKPSKRPAWDLKGQLCDLNAELKRCRERTQTLDQENQQLQDQLRDAQQQVKALGTERTTLEGHLAKVQAQAEQGQQELKNLRACVLELEERLSTQEGLVQELQKKQVELQEERRGLMSQLEEKERRLQTSEAALSSSQAEVASLRQETVAQAALLTEREERLHGLEMERRRLHNQLQELKGNIRVFCRVRPVLPGEPTPPPGLLLFPSGPGGPSDPPTRLSLSRSDERRGTLSGAPAPPTRHDFSFDRVFPPGSGQDEVFEEIAMLVQSALDGYPVCIFAYGQTGSGKTFTMEGGPGGDPQLEGLIPRALRHLFSVAQELSGQGWTYSFVASYVEIYNETVRDLLATGTRKGQGGECEIRRAGPGSEELTVTNARYVPVSCEKEVDALLHLARQNRAVARTAQNERSSRSHSVFQLQISGEHSSRGLQCGAPLSLVDLAGSERLDPGLALGPGERERLRETQAINSSLSTLGLVIMALSNKESHVPYRNSKLTYLLQNSLGGSAKMLMFVNISPLEENVSESLNSLRFASKVNQCVIGTAQANRK
  
Inhibitor
Name:
BDBM50037969
Synonyms:
CHEMBL3358268
Type:
Small organic molecule
Emp. Form.:
C33H43N3O4
Mol. Mass.:
545.7122
SMILES:
COCc1cc(ccc1OC)C(=O)NC(Cc1ccc(cc1)-c1cccc(c1)C(C)(C)C)C(=O)NCCN(C)C
Structure:
Search PDB for entries with ligand similarity: