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Target
RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Ligand
BDBM50054344
Substrate
n/a
Meas. Tech.
ChEMBL_1458325 (CHEMBL3369287)
IC50
1300±n/a nM
Citation
 Zeng, LF; Zhang, RY; Yu, ZH; Li, S; Wu, L; Gunawan, AM; Lane, BS; Mali, RS; Li, X; Chan, RJ; Kapur, R; Wells, CD; Zhang, ZY Therapeutic potential of targeting the oncogenic SHP2 phosphatase. J Med Chem 57:6594-609 (2014) [PubMed]  Article 
Target
Name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Synonyms:
CTD phosphatase SSU72 | PNAS-120 | RNA polymerase II subunit A C-terminal domain phosphatase SSU72 | SSU72 | SSU72_HUMAN
Type:
Enzyme
Mol. Mass.:
22567.68
Organism:
Homo sapiens (Human)
Description:
Q9NP77
Residue:
194
Sequence:
MPSSPLRVAVVCSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKLPGPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGILHMLDRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVVEDLNSREQETCQPVHVVNVDIQDNHEEATLGAFLICELCQCIQHTEDMENEIDELLQEFEEKSGRTFLHTVCFY
  
Inhibitor
Name:
BDBM50054344
Synonyms:
CHEMBL3319356 | US9522881, 11a-1 L97M74 | US9844535, ID 11a-1 L97M74
Type:
Small organic molecule
Emp. Form.:
C28H20IN3O5S
Mol. Mass.:
637.445
SMILES:
Cn1c(c(I)c2cc(C(O)=O)c(O)cc12)-c1cccc(NC(=O)C(=O)Nc2ccc(cc2)-c2ccsc2)c1
Structure:
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