Target
Activin receptor type-1
Ligand
BDBM50056508
Substrate
n/a
Meas. Tech.
ChEMBL_1453218 (CHEMBL3365511)
IC50
4.0±n/a nM
Citation
 Mohedas, AHWang, YSanvitale, CECanning, PChoi, SXing, XBullock, ANCuny, GDYu, PB Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J Med Chem 57:7900-15 (2014) [PubMed]  Article 
Target
Name:
Activin receptor type-1
Synonyms:
ACVR1_MOUSE | ALK2 | ActR-I | ActRIA | Acvr | Acvr1 | Acvrlk2 | Tgfb1
Type:
Protein
Mol. Mass.:
57231.35
Organism:
Mus musculus
Description:
n/a
Residue:
509
Sequence:
MVDGVMILPVLMMMAFPSPSVEDEKPKVNQKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACILGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLAELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC
  
Inhibitor
Name:
BDBM50056508
Synonyms:
CHEMBL3341945
Type:
Small organic molecule
Emp. Form.:
C24H28N4O3
Mol. Mass.:
420.5041
SMILES:
COc1cc(cc(OC)c1OC)-c1cc(cnc1N)-c1ccc(cc1)N1CCNCC1
Structure:
Search PDB for entries with ligand similarity: