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Target
Reverse transcriptase
Ligand
BDBM50011181
Substrate
n/a
Meas. Tech.
ChEMBL_1450642 (CHEMBL3362706)
IC50
2500±n/a nM
Citation
 Lacbay, CM; Mancuso, J; Lin, YS; Bennett, N; Götte, M; Tsantrizos, YS Modular assembly of purine-like bisphosphonates as inhibitors of HIV-1 reverse transcriptase. J Med Chem 57:7435-49 (2014) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50011181
Synonyms:
(PFA)dihydroxyphosphinecarboxylic acid oxide | CHEMBL666 | FOSCARNET | Forscarnet | Foscarnet (PFA) | Foscavir | Phosphono-formic acid(PFA) | Phosphonoformate | dihydroxyphosphinecarboxylic acid oxide | dihydroxyphosphinecarboxylic acid oxide(PFA) | phosphonoformic acid(PFA)
Type:
Small organic molecule
Emp. Form.:
CH3O5P
Mol. Mass.:
126.0053
SMILES:
OC(=O)P(O)(O)=O
Structure:
Search PDB for entries with ligand similarity: