Target
Kynurenine 3-monooxygenase
Ligand
BDBM50072143
Substrate
n/a
Meas. Tech.
ChEMBL_1467938 (CHEMBL3413142)
IC50
1.5±n/a nM
Citation
 Toledo-Sherman, LMPrime, MEMrzljak, LBeconi, MGBeresford, ABrookfield, FABrown, CJCardaun, ICourtney, SMDijkman, UHamelin-Flegg, EJohnson, PDKempf, VLyons, KMatthews, KMitchell, WLO'Connell, CPena, PPowell, KRassoulpour, AReed, LReindl, WSelvaratnam, SFriley, WWWeddell, DAWent, NEWheelan, PWinkler, CWinkler, DWityak, JYarnold, CJYates, DMunoz-Sanjuan, IDominguez, C Development of a series of aryl pyrimidine kynurenine monooxygenase inhibitors as potential therapeutic agents for the treatment of Huntington's disease. J Med Chem 58:1159-83 (2015) [PubMed]  Article 
Target
Name:
Kynurenine 3-monooxygenase
Synonyms:
KMO | KMO_HUMAN
Type:
PROTEIN
Mol. Mass.:
55831.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1487479
Residue:
486
Sequence:
MDSSVIQRKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDTRVATFTRGRSINLALSHRGRQALKAVGLEDQIVSQGIPMRARMIHSLSGKKSAIPYGTKSQYILSVSRENLNKDLLTAAEKYPNVKMHFNHRLLKCNPEEGMITVLGSDKVPKDVTCDLIVGCDGAYSTVRSHLMKKPRFDYSQQYIPHGYMELTIPPKNGDYAMEPNYLHIWPRNTFMMIALPNMNKSFTCTLFMPFEEFEKLLTSNDVVDFFQKYFPDAIPLIGEKLLVQDFFLLPAQPMISVKCSSFHFKSHCVLLGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEMRAHVNSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAVDSLEQISNLISR
  
Inhibitor
Name:
BDBM50072143
Synonyms:
CHEMBL3407924
Type:
Small organic molecule
Emp. Form.:
C13H8N2O3
Mol. Mass.:
240.2142
SMILES:
OC(=O)c1cc(ncn1)-c1ccc2occc2c1
Structure:
Search PDB for entries with ligand similarity: