Target
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
Ligand
BDBM50082125
Substrate
n/a
Meas. Tech.
ChEMBL_1475279 (CHEMBL3425139)
IC50
>100000±n/a nM
Citation
 Boyd, SBrookfield, JLCritchlow, SECumming, IACurtis, NJDebreczeni, JDegorce, SLDonald, CEvans, NJGroombridge, SHopcroft, PJones, NPKettle, JGLamont, SLewis, HJMacFaull, PMcLoughlin, SBRigoreau, LJSmith, JMSt-Gallay, SStock, JKTurnbull, APWheatley, ERWinter, JWingfield, J Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3. J Med Chem 58:3611-25 (2015) [PubMed]  Article 
Target
Name:
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
Synonyms:
6-phosphofructo-2-kinase | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 | 6PF-2-K/Fru-2,6-P2ase 2 | 6PF-2-K/Fru-2,6-P2ase heart-type isozyme | F262_HUMAN | Fructose-2,6-bisphosphatase | PFK/FBPase 2 | PFKFB2
Type:
PROTEIN
Mol. Mass.:
58485.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109607
Residue:
505
Sequence:
MSGASSSEQNNNSYETKTPNLRMSEKKCSWASYMTNSPTLIVMIGLPARGKTYVSKKLTRYLNWIGVPTKVFNLGVYRREAVKSYKSYDFFRHDNEEAMKIRKQCALVALEDVKAYLTEENGQIAVFDATNTTRERRDMILNFAEQNSFKVFFVESVCDDPDVIAANILEVKVSSPDYPERNRENVMEDFLKRIECYKVTYRPLDPDNYDKDLSFIKVINVGQRFLVNRVQDYIQSKIVYYLMNIHVQPRTIYLCRHGESEFNLLGKIGGDSGLSVRGKQFAQALRKFLEEQEITDLKVWTSQLKRTIQTAESLGVPYEQWKILNEIDAGVCEEMTYAEIEKRYPEEFALRDQEKYLYRYPGGESYQDLVQRLEPVIMELERQGNVLVISHQAVMRCLLAYFLDKGADELPYLRCPLHTIFKLTPVAYGCKVETIKLNVEAVNTHRDKPTNNFPKNQTPVRMRRNSFTPLSSSNTIRRPRNYSVGSRPLKPLSPLRAQDMQEGAD
  
Inhibitor
Name:
BDBM50082125
Synonyms:
CHEMBL3421735
Type:
Small organic molecule
Emp. Form.:
C24H26N4O3S
Mol. Mass.:
450.553
SMILES:
CC(C)Cn1cc(C#N)c2cc(ccc12)S(=O)(=O)c1ccc(NC(=O)[C@@H]2CCCN2)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: