Reaction Details Report a problem with these data
Target
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
Ligand
BDBM50082136
Substrate
n/a
Meas. Tech.
ChEMBL_1475278 (CHEMBL3425138)
IC50
2530±n/a nM
Citation
Boyd, S; Brookfield, JL; Critchlow, SE; Cumming, IA; Curtis, NJ; Debreczeni, J; Degorce, SL; Donald, C; Evans, NJ; Groombridge, S; Hopcroft, P; Jones, NP; Kettle, JG; Lamont, S; Lewis, HJ; MacFaull, P; McLoughlin, SB; Rigoreau, LJ; Smith, JM; St-Gallay, S; Stock, JK; Turnbull, AP; Wheatley, ER; Winter, J; Wingfield, J Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3. J Med Chem 58:3611-25 (2015) [PubMed] Article
More Info.:
Target
Name:
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
Synonyms:
6-phosphofructo-2-kinase | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 | 6PF-2-K/Fru-2,6-P2ase 1 | 6PF-2-K/Fru-2,6-P2ase liver isozyme | F261_HUMAN | F6PK | F6PK | Fructose-2,6-bisphosphatase | PFK/FBPase 1 | PFKFB1 | PFRX
Type:
PROTEIN
Mol. Mass.:
54681.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109606
Residue:
471
Sequence:
MSPEMGELTQTRLQKIWIPHSSGSSRLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYISTKLTRYLNWIGTPTKVFNLGQYRREAVSYKNYEFFLPDNMEALQIRKQCALAALKDVHNYLSHEEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPGIIAENIRQVKLGSPDYIDCDREKVLEDFLKRIECYEVNYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHIQSRTVYYLMNIHVTPRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLKVWTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCKVESIYLNVEAVNTHREKPENVDITREPEEALDTVPAHY