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Target
Dual specificity protein phosphatase 6
Ligand
BDBM82577
Substrate
n/a
Meas. Tech.
ChEMBL_1476409 (CHEMBL3430039)
IC50
>100000±n/a nM
Citation
 Tautz, L; Senis, YA; Oury, C; Rahmouni, S Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy. Bioorg Med Chem 23:2786-97 (2015) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 6
Synonyms:
DUS6_HUMAN | DUSP6 | Dual specificity protein phosphatase PYST1 | MAP kinase phosphatase 3 | MKP3 | Mitogen-activated protein kinase phosphatase 3 | PYST1
Type:
PROTEIN
Mol. Mass.:
42305.16
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1476409
Residue:
381
Sequence:
MIDTLRPVPFASEMAISKTVAWLNEQLELGNERLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRGEDRDRFTRRCGTDTVVLYDESSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFSLHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYFTTPSNQNVYQVDSLQST
  
Inhibitor
Name:
BDBM82577
Synonyms:
(4-fluoro-1,3-benzothiazol-2-yl)-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]amine | MLS-0437605.0002 | N-(4-fluoranyl-1,3-benzothiazol-2-yl)-5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-amine | N-(4-fluoro-1,3-benzothiazol-2-yl)-5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-amine | cid_7158830
Type:
Small organic molecule
Emp. Form.:
C16H11FN4O2S
Mol. Mass.:
342.348
SMILES:
COc1ccc(cc1)-c1nnc(Nc2nc3c(F)cccc3s2)o1
Structure:
Search PDB for entries with ligand similarity: