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TargetLactate dehydrogenase B (LDHB)
LigandBDBM50089924
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1499430
IC50 230±n/a nM
Citation Labadie, SDragovich, PSChen, JFauber, BPBoggs, JCorson, LBDing, CZEigenbrot, CGe, HHo, QLai, KWMa, SMalek, SPeterson, DPurkey, HERobarge, KSalphati, LSideris, SUltsch, MVanderPorten, EWei, BXu, QYen, IYue, QZhang, HZhang, XZhou, A Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase. Bioorg Med Chem Lett25:75-82 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lactate dehydrogenase B (LDHB)
Name:L-lactate dehydrogenase B chain
Synonyms:L-lactate dehydrogenase B | LDH heart subunit | LDH-B | LDH-H | Renal carcinoma antigen NY-REN-46
Type:Oxidoreductase; homotetramer
Mol. Mass.:36635.55
Organism:Homo sapiens (Human)
Description:n/a
Residue:334
Sequence:
MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLK
GEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKF
IIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLG
IHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAY
EVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARG
LTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50089924
NameBDBM50089924
Synonyms:CHEMBL3581203
TypeSmall organic molecule
Emp. Form.C24H18Cl3NO3S
Mol. Mass.506.829
SMILESCOc1ccc(Cl)c(SC2=C(O)CC(CC2=O)c2c(Cl)ccc(c2Cl)-c2ccncc2)c1 |c:9|
Structure
n/a