Target
L-lactate dehydrogenase B chain
Ligand
BDBM50089927
Substrate
n/a
Meas. Tech.
ChEMBL_1499430 (CHEMBL3583865)
IC50
410±n/a nM
Citation
 Labadie, SDragovich, PSChen, JFauber, BPBoggs, JCorson, LBDing, CZEigenbrot, CGe, HHo, QLai, KWMa, SMalek, SPeterson, DPurkey, HERobarge, KSalphati, LSideris, SUltsch, MVanderPorten, EWei, BXu, QYen, IYue, QZhang, HZhang, XZhou, A Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase. Bioorg Med Chem Lett 25:75-82 (2015) [PubMed]  Article 
Target
Name:
L-lactate dehydrogenase B chain
Synonyms:
L-lactate dehydrogenase B | L-lactate dehydrogenase B chain | LDH heart subunit | LDH-B | LDH-H | LDHB | LDHB_HUMAN | Lactate dehydrogenase B (LDHB) | Renal carcinoma antigen NY-REN-46
Type:
Oxidoreductase; homotetramer
Mol. Mass.:
36635.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
334
Sequence:
MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL
  
Inhibitor
Name:
BDBM50089927
Synonyms:
CHEMBL3581200
Type:
Small organic molecule
Emp. Form.:
C22H21Cl3O4S
Mol. Mass.:
487.824
SMILES:
COc1ccc(Cl)c(SC2=C(O)CC(CC2=O)c2c(Cl)ccc(OC(C)C)c2Cl)c1 |c:9|
Structure:
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