Target
L-lactate dehydrogenase A chain
Ligand
BDBM50089933
Substrate
n/a
Meas. Tech.
ChEMBL_1499429 (CHEMBL3583864)
IC50
130±n/a nM
Citation
 Labadie, SDragovich, PSChen, JFauber, BPBoggs, JCorson, LBDing, CZEigenbrot, CGe, HHo, QLai, KWMa, SMalek, SPeterson, DPurkey, HERobarge, KSalphati, LSideris, SUltsch, MVanderPorten, EWei, BXu, QYen, IYue, QZhang, HZhang, XZhou, A Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase. Bioorg Med Chem Lett 25:75-82 (2015) [PubMed]  Article 
Target
Name:
L-lactate dehydrogenase A chain
Synonyms:
Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59
Type:
Protein
Mol. Mass.:
36694.85
Organism:
Homo sapiens (Human)
Description:
P00338::PDB Code: 4ajp
Residue:
332
Sequence:
MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF
  
Inhibitor
Name:
BDBM50089933
Synonyms:
CHEMBL3581195
Type:
Small organic molecule
Emp. Form.:
C22H19Cl3O4S
Mol. Mass.:
485.808
SMILES:
CCOC(=O)Cc1ccc(Cl)c(SC2=C(O)CC(CC2=O)c2c(Cl)cccc2Cl)c1 |c:13|
Structure:
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