Target
Cathepsin D
Ligand
BDBM50092467
Substrate
n/a
Meas. Tech.
ChEMBL_1500716 (CHEMBL3588066)
IC50
>300000±n/a nM
Citation
 Winneroski, LLSchiffler, MAErickson, JAMay, PCMonk, SATimm, DEAudia, JEBeck, JPBoggs, LNBorders, ARBoyer, RDBrier, RAHudziak, KJKlimkowski, VJGarcia Losada, PMathes, BMStout, SLWatson, BMMergott, DJ Preparation and biological evaluation of conformationally constrained BACE1 inhibitors. Bioorg Med Chem 23:3260-8 (2015) [PubMed]  Article 
Target
Name:
Cathepsin D
Synonyms:
CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor
Type:
Enzyme
Mol. Mass.:
44551.72
Organism:
Homo sapiens (Human)
Description:
Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.
Residue:
412
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
  
Inhibitor
Name:
BDBM50092467
Synonyms:
CHEMBL3586137
Type:
Small organic molecule
Emp. Form.:
C14H18ClFN4OS
Mol. Mass.:
344.835
SMILES:
Cl.NC1=NC2CCC(CC2CS1)NC(=O)c1ccc(F)cn1 |t:1|
Structure:
Search PDB for entries with ligand similarity: