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Target
Beta-secretase 2
Ligand
BDBM50092472
Substrate
n/a
Meas. Tech.
ChEMBL_1500715 (CHEMBL3588065)
IC50
11100±n/a nM
Citation
 Winneroski, LL; Schiffler, MA; Erickson, JA; May, PC; Monk, SA; Timm, DE; Audia, JE; Beck, JP; Boggs, LN; Borders, AR; Boyer, RD; Brier, RA; Hudziak, KJ; Klimkowski, VJ; Garcia Losada, P; Mathes, BM; Stout, SL; Watson, BM; Mergott, DJ Preparation and biological evaluation of conformationally constrained BACE1 inhibitors. Bioorg Med Chem 23:3260-8 (2015) [PubMed]  Article 
Target
Name:
Beta-secretase 2
Synonyms:
AEPLC | ALP56 | ASP1 | ASP21 | Asp 1 | Aspartic-like protease 56 kDa | Aspartyl protease 1 | BACE2 | BACE2_HUMAN | Beta secretase 2 | Beta-secretase (BACE) | Beta-secretase 2 | Beta-secretase 2 (BACE-2) | Beta-secretase 2 precursor | Beta-site APP-cleaving enzyme 2 | Down region aspartic protease | Memapsin-1 | Membrane-associated aspartic protease 1 | beta-Secretase (BACE-2)
Type:
Protein
Mol. Mass.:
56171.20
Organism:
Homo sapiens (Human)
Description:
Q9Y5Z0
Residue:
518
Sequence:
MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK
  
Inhibitor
Name:
BDBM50092472
Synonyms:
CHEMBL3586138
Type:
Small organic molecule
Emp. Form.:
C15H20ClN3OS
Mol. Mass.:
325.857
SMILES:
Cl.NC1=NC2CCC(CC2CS1)NC(=O)c1ccccc1 |t:1|
Structure:
Search PDB for entries with ligand similarity: