Target
Beta-secretase 2
Ligand
BDBM50092467
Substrate
n/a
Meas. Tech.
ChEMBL_1500715 (CHEMBL3588065)
IC50
26300±n/a nM
Citation
 Winneroski, LLSchiffler, MAErickson, JAMay, PCMonk, SATimm, DEAudia, JEBeck, JPBoggs, LNBorders, ARBoyer, RDBrier, RAHudziak, KJKlimkowski, VJGarcia Losada, PMathes, BMStout, SLWatson, BMMergott, DJ Preparation and biological evaluation of conformationally constrained BACE1 inhibitors. Bioorg Med Chem 23:3260-8 (2015) [PubMed]  Article 
Target
Name:
Beta-secretase 2
Synonyms:
AEPLC | ALP56 | ASP1 | ASP21 | Asp 1 | Aspartic-like protease 56 kDa | Aspartyl protease 1 | BACE2 | BACE2_HUMAN | Beta secretase 2 | Beta-secretase (BACE) | Beta-secretase 2 | Beta-secretase 2 (BACE-2) | Beta-secretase 2 precursor | Beta-site APP-cleaving enzyme 2 | Down region aspartic protease | Memapsin-1 | Membrane-associated aspartic protease 1 | beta-Secretase (BACE-2)
Type:
Protein
Mol. Mass.:
56171.20
Organism:
Homo sapiens (Human)
Description:
Q9Y5Z0
Residue:
518
Sequence:
MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK
  
Inhibitor
Name:
BDBM50092467
Synonyms:
CHEMBL3586137
Type:
Small organic molecule
Emp. Form.:
C14H18ClFN4OS
Mol. Mass.:
344.835
SMILES:
Cl.NC1=NC2CCC(CC2CS1)NC(=O)c1ccc(F)cn1 |t:1|
Structure:
Search PDB for entries with ligand similarity: