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Target
Nucleophosmin
Ligand
BDBM50094237
Substrate
n/a
Meas. Tech.
ChEMBL_1502709 (CHEMBL3590705)
EC50
9700±n/a nM
Citation
 Penthala, NR; Crooks, PA; Freeman, ML; Sekhar, KR Development and validation of a novel assay to identify radiosensitizers that target nucleophosmin 1. Bioorg Med Chem 23:3681-6 (2015) [PubMed]  Article 
Target
Name:
Nucleophosmin
Synonyms:
NPM | NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) | NPM1 | NPM_HUMAN
Type:
PROTEIN
Mol. Mass.:
32552.99
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1502715
Residue:
294
Sequence:
MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVEEDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKSIRDTPAKNAQKSNQNGKDSKPSSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL
  
Inhibitor
Name:
BDBM50094237
Synonyms:
CHEMBL593574
Type:
Small organic molecule
Emp. Form.:
C21H14N4O3
Mol. Mass.:
370.3609
SMILES:
O=[#6]-1-[#7]-[#6](=O)\[#6](=[#6]/c2cn(-[#6]-c3ccc(cc3)C#N)c3ccccc23)-[#6](=O)-[#7]-1
Structure:
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