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Target
2-acylglycerol O-acyltransferase 2
Ligand
BDBM50110518
Substrate
n/a
Meas. Tech.
ChEMBL_1510040 (CHEMBL3606132)
IC50
1170±n/a nM
Citation
 Busujima, T; Tanaka, H; Shirasaki, Y; Munetomo, E; Saito, M; Kitano, K; Minagawa, T; Yoshida, K; Osaki, N; Sato, N Identification of 2-[2-(4-tert-butylphenyl)ethyl]-N-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide (29) as an orally available MGAT2 inhibitor. Bioorg Med Chem 23:5922-31 (2015) [PubMed]  Article 
Target
Name:
2-acylglycerol O-acyltransferase 2
Synonyms:
2-acylglycerol O-acyltransferase 2 | Acyl-CoA:monoacylglycerol acyltransferase 2 | Dgat2l5 | Dgat2l5 | Diacylglycerol acyltransferase 2-like protein 5 | MGAT2 | MOGT2_MOUSE | Mgat1l | Mogat2 | Monoacylglycerol O-acyltransferase 1-like | Monoacylglycerol O-acyltransferase 2
Type:
PROTEIN
Mol. Mass.:
38606.94
Organism:
Mus musculus
Description:
ChEMBL_109857
Residue:
334
Sequence:
MVEFAPLLVPWERRLQTFAVLQWVFSFLALAQLCIVIFVGLLFTRFWLFSVLYATWWYLDWDKPRQGGRPIQFFRRLAIWKYMKDYFPVSLVKTAELDPSRNYIAGFHPHGVLAAGAFLNLCTESTGFTSLFPGIRSYLMMLTVWFRAPFFRDYIMSGGLVSSEKVSADHILSRKGGGNLLAIIVGGAQEALDARPGAYRLLLKNRKGFIRLALMHGAALVPIFSFGENNLFNQVENTPGTWLRWIQNRLQKIMGISLPLFHGRGVFQYSFGLMPFRQPITTIVGKPIEVQMTPQPSREEVDRLHQRYIKELCKLFEEHKLKFNVPEDQHLEFC
  
Inhibitor
Name:
BDBM50110518
Synonyms:
CHEMBL3605835
Type:
Small organic molecule
Emp. Form.:
C27H31FN2O2S
Mol. Mass.:
466.611
SMILES:
CC(C)(C)c1ccc(CCN2CCc3cc(ccc3C2)S(=O)(=O)Nc2ccc(F)cc2)cc1
Structure:
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